產品屬性：
產品名稱 | Sodium Danshensu |
規格 | 10mg、20mg、500mg、1g |
貨號 | EY-01Y19608 |
Cas No.: 67920-52-9
別名: N/A
化學名: sodium;3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate
分子式: C9H10O5.Na
分子量: 221.04
溶解度: ≥ 22.1mg/mL in H2O with gentle warming
儲存條件: Store at 2-8°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2]
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