產品屬性：
產品名稱 | S-Adenosylhomocysteine |
規格 | 10mg、25mg、50mg |
貨號 | EY-01Y18060 |
Cas No.: 979-92-0
別名: N/A
化學名: (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid
分子式: C14H20N6O5S
分子量: 384.41
溶解度: ≥ 8.56 mg/mL in DMSO with ultrasonic and warming, ≥ 45.3 mg/mL in H2O with gentle warming
儲存條件: Store at -20°C, protect from light
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
S-adenosylhomocysteine, an amino acid derivative in metabolic pathways, is an intermediate in the synthesis of adenosine and cysteine.
In vitro: Previous study found that cystathionine β-synthase (CBS) deficient yeast could transport significantly more homocysteine into the media than wild-type yeast and had elevated homocysteine and S-adenosylhomocysteine (SAH). Moreover, it was found that SAH at 25 μM inhibited the growth of CBS deficient yeast, whereas had no effect on wild-type yeast. In addition, the measurement results of the intracellular S-adenosylmethionine (SAM) and SAH indicated that CBS deficient yeast had reduced SAM/SAH ratios when compared withy wild-type. Meanwhile, the growth inhibition by SAH in CBS deficient yeast could be reversed by addition of SAM to the media, suggesting that the ratio but not absolute level was critical for cell growth [1].
In vivo: The tissue distribution of SAH was found to be similar in both rat sexes, and was only slightly changed with age. The specific activity of SAH hydrolase exceeded that of methionine adenosyltransferase greatly, and the S-adenosylmethionine concentration was higher than that of S-adenosylhomocysteine in all examined tissues. However, the hepatic S-adenosylmethionine/SAH ratio was dependent on food supply and on the age of the animal. IP administration of methionine led to a profound but transient increase in the liver concentrations of S-adenosylmethionine and SAH [2].
Clinical trial: Up to now, S-adenosylhomocysteine is not applied for clinical usage.
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