產(chǎn)品屬性：
產(chǎn)品名稱 | PFM39 |
規(guī)格 | 25 mg、50 mg、100 mg |
貨號 | EY-01Y18066 |
Cas No.: 1310744-67-2
別名: N/A
化學名: N/A
分子式: C10H9N3OS
分子量: 219.26
溶解度: N/A
儲存條件: 4°C, protect from light
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibits TmMre11 or human MRE11/MRN endonuclease activity[1].PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR)[1]. PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ[1].[1]. Atsushi Shibata , et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18.
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