產品屬性：
產品名稱 | Propionyl-L-carnitine-d3 (chloride) |
規(guī)格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y15373 |
Cas No.: 1334532-19-2
別名: N/A
化學名: N/A
分子式: C10H17D3NO4.Cl
分子量: 256.7
溶解度: DMF: 15 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Propionyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of propionyl-L-carnitine by GC- or LC-MS. Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.1 Propionyl-L-carnitine increases the basal release of prostaglandin E2 and 6-keto Prostaglandin F1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 in non-contaminated cells.1 It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.2 Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.31.Garrelds, I.M., Elliott, G.R., Pruimboom, W.M., et al.Effects of carnitine and its congeners on eicosanoid discharge from rat cells: Implications for release of TNFαMediators of Inflammation2(7)S57-S62(1993)
2.Stasi, M.A., Scioli, M.G., Arcuri, G., et al.Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide productionArterioscler. Thromb. Vasc. Biol.30(3)426-435(2010)
3.Ferrari, R., Ceconi, C., Cargnoni, A., et al.The effect of propionyl-L-carnitine on the ischemic and reperfused intact myocardium and on their derived mitochondriaCardiovasc. Drugs Ther.5 (Suppl 1)57-65(1991)
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