產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | VU0238441 |
規(guī)格 | 5mg、10mg、25mg、50mg、100mg |
貨號(hào) | EY-01Y14461 |
Cas No.: 85511-68-8
別名: N/A
化學(xué)名: N/A
分子式: C16H9ClF3NO2
分子量: 339.7
溶解度: DMSO: 125 mg/mL (367.97 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].VU0238441 is an analogue of VU0119498[2].[1]. Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62.
[2]. Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8.
特別提醒公司產(chǎn)品僅供科研使用
