產品屬性：
產品名稱 | SAH-SOS1A |
規(guī)格 | 500 ug |
貨號 | EY-01Y12078 |
Cas No.: 1652561-87-9
別名: N/A
化學名: N/A
分子式: C100H159N27O28
分子量: 2187.53
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.Leshchiner et al (2015) Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proc.Natl.Acad.Sci.USA. 112 1761 PMID:25624485
特別提醒公司產品僅供科研使用
