產(chǎn)品屬性：
產(chǎn)品名稱 | Se-Methylselenocysteine (hydrochloride) |
規(guī)格 | 25mg、50mg、100mg、250mg |
貨號 | EY-01Y9581 |
Cas No.: 863394-07-4
別名: N/A
化學(xué)名: N/A
分子式: C4H9NO2Se ?HCl
分子量: 218.6
溶解度: DMF: 1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Se-Methylselenocysteine is a selenium-containing amino acid that has been found in Allium and has antioxidative and anticancer augmenting activities.1,2 Se-Methylselenocysteine (0.01-10 μM) prevents tert-butyl hydroperoxide-induced increases in malondialdehyde (MDA) levels and glutathione reductase and glutathione peroxidase (GPX) activity, as well as decreases in glutathione (GSH) levels, in HepG2 cells.1 It has an additive effect on irinotecan-induced tumor growth reduction in a FaDu mouse xenograft model when administered at a dose of 5 μg/animal per day.21.Cuello, S., Ramos, S., Mateos, R., et al.Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxideAnal. Bioanal. Chem.389(7-8)2167-2178(2007)
2.Azrak, R.G., Cao, S., Pendyala, L., et al.Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependentBiochem. Pharmacol.73(9)1280-1287(2007)
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